It's good to see that this kind of research is being done, but having read the abstract of the article I can't help but feel a little anxious.

This is a treatment against leukemia, but previous gene therapy research (about CD34 instead of CD19) has shown that modifying cells in the immune system (or associated with them) with retroviral transduction techniques can in turn cause leukemia itself. The goals of these two studies are very different but the potential side effects are very similar.

Now the enormous difference is that gene therapy is in vivo transduction and that the transduction in this study was done in vitro but was performed, like gene therapy, using retroviral transduction. Retroviral transduction has the potential downside of incorporating genetic material into unfortunate places like protooncogenic promotors/genes, which could promote unwanted (over)expression of said protooncogenes.


I got picked as second tier bridesmaid. And what that boiled down to was that in the event that any of the other bridesmaids couldn't fulfill their role I was jump in.

What it turned out to be was me folding, stuffing, and addressing tons of wedding invitations for a rustic wedding.

Personally, I am not a fan of cutesy poems in wedding literature. And technically, suggested dress is not traditionally mentioned on an invitation. That said, no one knows that because everyone does it anyway. But I had to grimace just a little while I was doing the aforementioned task. Why? They stipulated what was to be worn.

I decided, rather than complaining, I would simply addressed the matter on my website.

Regarding Dress Code

Be careful with telling guests how to dress, especially casual. For example, I want to call my wedding relaxing and casual, but I mean this in the sense of not super structured, plated dinner, formal dancing time, etc. But I wouldn't tell my guests that my wedding is casual, because that could means jeans or shorts to them, and show up whenever you want ordeal.

But if you don't mind that, then go for it! Honestly, your guests have been to plenty of weddings before and they don't need attire advice. I would see that your wedding is at a rustic barn and outdoors, and know not to wear a cocktail dress, but a cute summer dress with sandals.

All In All

I had fun. It was some work, but I didn't expect to be in the wedding. Not really, and I got to spend an afternoon or two helping.

It was easy since we took the earliest date that vendors needed to know and put a RSVP due date that was 2 weeks before the earliest vendor due date. So with your RSVPs, you need to know answers 6 weeks before.

This is the timeline we had. Wedding was end of Dec, one vendor needed final count 1 month in advance so end of Nov. We made RSVP due date be early Oct giving us a 2 week cushion. We sent out invites end of Aug/ early Sept giving folks 1 month to respond.

Then the 2 weeks after the due date and before the vendor due date was spent chasing/calling folks who had not responded.

Seems reasonable to me, but I don't know a lot of the invitation etiquette.


The number of foreign workers in Japan surpassed 1 million for the first time last year, as the labor-strapped country struggles to find enough Japanese workers.

Prime Minister Shinzo Abe has said the country should put more Japanese women and the elderly to work first before accepting immigrants, but policymakers are exploring ways to bring in more foreign workers without calling it "Immigration".

Vietnamese workers were in second place, accounting for around 16 per cent of the total foreign workers but up over 50 per cent compared to the previous year.

Why would someone go out of their way to work in japan in the first place? Their work culture is even worse than the US's culture and no matter how well you perform you'll always be treated as a foreigner.

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Funding effective family planning in developing countries is money well spent.

Canada's minister for international development has spoken with her Dutch counterpart about a proposal by the Netherlands to fund abortions overseas in the wake of President Donald Trump's move to ban American funding for such services.

Lilianne Ploumen, the Dutch minister of foreign trade and development co-operation, announced her desire to establish an international fund earlier this week after Trump signed an executive order that prohibits funding to international organizations that promote or perform abortion.

Bibeau's office says she and Ploumen have spoken on a regular basis about sexual and reproductive rights, including abortion.

Promoting abstinence straight up doesn't work. This has led to a huge amount of utterly wasted resources on account of those people who insist on having ideology rule the day rather than relying on evidence and results based policies.

Providing access to family planning resources results in fewer unintended pregnancies and fewer abortions - and those that are carried out are done so in a safe and professional way. These are very good things, but they are completely lost on those who are content to see US abortion politics outsourced to foreign aid policy. Glad to see these countries pulling up the slack for Trump's farcical behavior here.


The pressure of deep-ocean sound waves could be used to stop tsunamis in their tracks, researchers have found, by dissipating their energy across wider areas and reducing the height and speed of these monster waves before they reach land.

Tsunamis - which can be caused by earthquakes, landslides, or any sudden release of energy underwater - are capable of devastating coastal regions when they hit land, and right now, there's not much we can do to stop them.

But mathematician Usama Kadri from the University of Cardiff in the UK thinks acoustic-gravity waves (AGWs) could be the solution.

Acoustic-gravity waves occur naturally in the oceans, cutting through the water at the speed of sound, and Kadri says controlling these waves could give us a way of reducing a tsunami's momentum.

"Up until now, little attention has been paid to trying to mitigate tsunamis and the potential of acoustic-gravity waves remains largely unexplored," says Kadri.

AGWs can stretch for hundreds of kilometres, and travel many thousands of metres, and it's thought that plankton (which can't swim themselves) rely on these waves to move around and find food.


I have two feral cats adopted at different ages and time cuddled up with me right now.

One was found about 4 weeks of age. He is about 8 years old now. The other moved in at around 4 month's old, she is about 3 years old now. She only stopped acting feral and turned into a cuddly cat a few months ago.

When you finally manage to earn their trust is the greatest feeling.

Give them food and make sure they see you giving it to them. Sit in view of the food bowl. Move the food bowl closer to you daily. When the food bowl is right next to you, bother them by touching briefly. Do this until they no longer get scared of the touching and you can pet them for prolonged times.

This might be weird but you might want to separate kitten from mother to work solo with it as the mothers fear or hate to people can be learned quickly by the kitten. Older cats are also a lot harder to get tamed.

Source: I have two 8-12 week old kittens in a spare room and am working with them daily. I found them in my crawl space a week ago and took the mother to the vet to be fixed and let her go. They make progress slowly as they learned to be afraid of me from their mother.